Engineering
2 years ago

High D-xylose levels in yeast lead to accelerated death.

Research Square (Research Square)
D-xylose accelerated death of pentose metabolizing Saccharomyces cerevisiae
Jeroen G. Nijland, Xiaohuan Zhang, Arnold J. M. Driessen

Paper Summary

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The researchers found that high levels of a protein called Xks1 in yeast cells can lead to decreased growth and ATP levels when consuming D-xylose. By controlling the expression of Xks1, they were able to restore growth and increase ATP levels, improving the efficiency of D-xylose metabolism. This study highlights the importance of balancing Xks1 levels for optimal yeast growth in high D-xylose conditions.