Genetically diverse chimeras offer new insights into myelination disorders.
Chimeras are animals made up of cells from different fertilized eggs, allowing scientists to study how different cells interact. This is different from cell fusion. Researchers created mice with cells from normal and mutant animals to see how mutations affect cell behavior. They found that in these chimeras, patches of mutant cells were surrounded by normal cells in the brain's white matter. This shows how mutations can affect cell behavior at a cellular level.