Biochemistry, Genetics and Molecular Biology
2 years ago

Unlocking Evolution's Secrets: How Global Epistasis Shapes Adaptive Landscapes.

Philosophical Transactions of the Royal Society B Biological Sciences
Global epistasis on fitness landscapes
Juan Díaz‐Colunga, Abigail Skwara, Karna Gowda, Ramón Díaz‐Uriarte, Mikhail Tikhonov, Djordje Bajić, Álvaro Sánchez

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Global epistasis, or how mutations interact with each other, can actually help us understand evolution better. By studying how mutations affect fitness in different genetic backgrounds, we can predict how organisms evolve. The way mutations interact can vary, from making each other's effects weaker to making them stronger. This helps us see how evolution might happen in real life.