Biochemistry, Genetics and Molecular Biology
18 days ago

Synonymous mutations in yeast found to be more harmful than previously thought.

Molecular Biology and Evolution
Further evidence for strong non-neutrality of yeast synonymous mutations
Xukang Shen, Siliang Song, Chuan Li, Jianzhi Zhang

Paper Summary

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Synonymous mutations in yeast were thought to be neutral, but recent research shows they can actually be harmful. Scientists studied thousands of yeast mutants with different mutations and found that most synonymous and nonsynonymous mutations are bad for the yeast. Some mutations were thought to be caused by editing errors, but further analysis showed this wasn't the case. The study confirms that many synonymous mutations can have negative effects on yeast, challenging the idea that they are mostly harmless.