The article argues that understanding how something works is important, especially in medicine. The authors disagree with the idea that we can benefit from something without knowing how it works, like gravity or anesthesia. They say that before we can use a treatment, we need to be sure it actually works. This is a big debate in their field, and they agree that only strong evidence from a big study can settle it. They quote Isaac Newton to emphasize that quality is more important than quantity when it comes to evidence.