The study aimed to understand how two factors, NF-κB and AT1R, contribute to non-alcoholic fatty liver disease (NAFLD) in rats. Rats were fed a high-fat diet and then treated with a substance to block NF-κB. Results showed that as NAFLD worsened, NF-κB activity increased, and blocking NF-κB reduced AT1R levels in the liver. This suggests that targeting NF-κB could be a potential strategy to help with NAFLD.