Mutant p53 proteins in cancer activate unrelated transcription factors, not just p63 and p73, revealing new therapeutic possibilities.
The p53 family of proteins, including mutants and isoforms, have different functions in cancer. Mutant p53 can stop p53 from working properly, but also activate other genes not related to p53. This raises questions about how mutant p53 affects other family members like p63 and p73. The research discusses how mutant p53 interacts with family members and other proteins, and how this affects cancer development and potential treatments.
